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Nitrofurantoin-induced interstitial pneumonitis: albeit rare, should not be missed
Haamid Syed1, Ghassan Bachuwa1, Sunil Upadhaya1
1Department of Internal Medicine, Hurley Medical Center/Michigan State University, Flint, Michigan, USA.
Abstract:
Interstitial lung disease (ILD) is a rare adverse effect of nitrofurantoin and can range from benign infiltrates to a fatal condition. Nitrofurantoin acts via inhibiting the protein synthesis in bacteria by helping reactive intermediates and is known to produce primary lung parenchymal injury through an oxidant mechanism. Stopping the drug leads to complete recovery of symptoms. In this report, we present a case of nitrofurantoin-induced ILD with the recovery of symptoms and disease process after stopping the drug.
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