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Related Experiment Video

Updated: Jul 19, 2026

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Occupational hypersensitivity pneumonitis: an EAACI position paper.

S Quirce1, O Vandenplas2, P Campo3

  • 1Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Allergy
|February 26, 2016
PubMed
Summary

Occupational hypersensitivity pneumonitis (OHP) is an immune lung disease from workplace exposures. Early diagnosis and removal from the antigen are crucial for managing OHP, though outcomes can vary.

Keywords:
diagnosisextrinsic allergic alveolitishypersensitivity pneumonitisoccupational disease

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Area of Science:

  • Pulmonary Medicine
  • Occupational Health
  • Immunology

Background:

  • Occupational hypersensitivity pneumonitis (OHP) is an immunologic lung disease.
  • It results from lymphocytic and granulomatous inflammation due to allergic reactions to workplace agents.
  • Agents include bacteria, fungi, animal/plant proteins, chemicals, and metals.

Purpose of the Study:

  • To critically review current knowledge on OHP.
  • To propose practical guidance for OHP diagnosis and management.
  • To highlight the work-related nature of the disease.

Main Methods:

  • Multidisciplinary approach for diagnosis.
  • Combination of diagnostic tests to confirm work-relatedness.
  • Emphasis on clinical and occupational history for initial suspicion.

Main Results:

  • OHP involves inflammation of airways, alveoli, and interstitial tissue.
  • Diagnosis relies on identifying the offending antigen and its workplace source.
  • Proposed diagnostic criteria for OHP.

Conclusions:

  • Early removal from antigen exposure is the primary treatment for OHP.
  • OHP management requires a comprehensive approach.
  • Adverse outcomes are possible even after antigen avoidance.