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Related Concept Videos

Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammation01:38

Inflammation

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Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
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Related Experiment Video

Updated: Mar 25, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
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SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

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Are dermal adipocytes involved in psoriasis?

Ilja L Kruglikov1, Philipp E Scherer2, Uwe Wollina3

  • 1Wellcomet GmbH, Karlsruhe, Germany.

Experimental Dermatology
|February 26, 2016
PubMed
Summary

Dermal fat cells, not those in deeper layers, appear to drive psoriasis inflammation. Therapies targeting psoriasis also impact these dermal fat cells, suggesting a key role in the disease.

Keywords:
cathelicidindermal adipocytespathophysiologypsoriasis

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Area of Science:

  • Dermatology
  • Immunology
  • Adipose tissue biology

Background:

  • Growing evidence links adipose tissue to psoriasis pathophysiology.
  • Skin's dermal adipose depot expands in response to pathogens, increasing antimicrobial peptides and exacerbating psoriasis inflammation.

Purpose of the Study:

  • To investigate the specific role of dermal adipocytes in psoriasis pathophysiology.
  • To test the hypothesis that dermal adipocytes, not subcutaneous adipose tissue, are central to psoriasis.

Main Methods:

  • Profiling adipocytes from psoriatic lesions.
  • Analyzing adipocyte changes before and after psoriasis-relevant therapies.

Main Results:

  • Therapeutic interventions for psoriasis modulate dermal adipose tissue.
  • Dermal adipocyte activity correlates with psoriasis-associated inflammation.

Conclusions:

  • Dermal adipocytes are implicated in the pathophysiology of psoriasis.
  • Targeting dermal adipocytes may offer novel therapeutic strategies for psoriasis.