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Does elevated peripheral benzodiazepine receptor gene expression relate to cognitive deficits in methamphetamine

Siriluk Veerasakul1,2, Samur Thanoi1,2, Paritat Watiktinkorn3

  • 1Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.

Human Psychopharmacology
|February 26, 2016
PubMed
Summary

Chronic methamphetamine (METH) abuse increases peripheral benzodiazepine receptor (PBR) gene expression, indicating systemic inflammation. This elevation persists over a year post-abstinence and correlates with cognitive deficits in METH-dependent individuals.

Keywords:
Wisconsin Card-Sorting Testcognitive functiongene expressionmethamphetamineperipheral benzodiazepine receptortranslocator protein 18 kDa

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