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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
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Assessment of Right Ventricular Afterload in COPD
Janne Mykland Hilde1,2, Ingunn Skjørten3,2, Viggo Hansteen1
1a 1 Department of Cardiology, Oslo University Hospital , Aker , Norway.
COPD
|February 26, 2016
Summary
Pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) in COPD patients can be accurately predicted using simple echocardiography methods. Heart rate-adjusted pulmonary acceleration-time (PAAcT) and right ventricular systolic velocity time integral (RVSmVTI) offer high feasibility and accuracy.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Pulmonary hypertension (PH) and elevated pulmonary vascular resistance (PVR) are common in COPD patients.
- Predicting PH and PVR in COPD without comorbidities is crucial.
- Conventional echocardiography and novel tissue Doppler imaging (TDI) were investigated.
Purpose of the Study:
- To assess the predictive capability of conventional echo Doppler and TDI for PH and PVR in COPD patients.
- To evaluate the feasibility and accuracy of specific echo Doppler indices.
Main Methods:
- Echocardiography and right heart catheterization in 100 COPD outpatients.
- Measurement of heart rate-adjusted RVSmVTI and PAAcT.
- Division into derivation (n=50) and validation (n=50) cohorts.
Main Results:
- RVSmVTI and PAAcT demonstrated high area under the curve for predicting PH (0.93) and elevated PVR (0.96).
- Both indices showed 100% feasibility, outperforming contrast-enhanced tricuspid regurgitation parameters (84%).
- PAAcT and RVSmVTI accurately calculated mean pulmonary artery pressure (mPAP) and PVR (90% and 78-84% accuracy).
Conclusions:
- Heart rate-adjusted PAAcT and RVSmVTI are simple, reproducible, and accurate methods for detecting PH and increased PVR in COPD.
- These indices demonstrate high feasibility and should be considered in echocardiographic assessments of COPD patients.
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