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Published on: March 25, 2019
Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells
Wei Shi1, Robert J Paproski2, Peng Shao1
1University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
Abstract:
A multimodality Raman and photoacoustic imaging system is presented. This system has ultralow background and can detect tumor cells labeled with modified surface-enhanced-Raman-scattering (SERS) nanoparticles in vivo. Photoacoustic imaging provides microvascular context and can potentially be used to guide magnetic trapping of circulating tumor cells for SERS detection in animal models.
