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Mushroom Lectins as Promising Anticancer Substances.
Ram Sarup Singh1, Hemant Preet Kaur, Jagat Rakesh Kanwar
1Carbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala 147002, Punjab, India. rssingh11@lycos.com.
Current Protein & Peptide Science
|February 27, 2016
Summary
Mushroom lectins show anti-proliferative effects, offering potential as novel antitumor drugs. Further research into their mechanisms can expand their use in cancer therapeutics.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Lectins are proteins/glycoproteins of non-immune origin that bind to carbohydrates.
- They can alter cell membrane physiology and trigger biochemical changes.
- Lectins have potential applications in cancer diagnostics and therapy by inducing apoptosis.
Purpose of the Study:
- To review the anti-proliferative activity of mushroom lectins.
- To discuss the mechanisms underlying their anti-proliferative effects.
- To explore the potential of mushroom lectins as novel antitumor drugs.
Main Methods:
- Review of in-vitro and in-vivo studies on mushroom lectins.
- Analysis of the mechanisms of anti-proliferative activity.
- Discussion of potential therapeutic applications.
Main Results:
- Mushroom lectins exhibit significant anti-proliferative activity.
- Various mechanisms contribute to their antitumor effects.
- Unique specificities of mushroom lectins offer biotechnological potential.
Conclusions:
- Mushroom lectins are promising candidates for cancer therapeutics.
- Understanding their action mechanisms is crucial for drug development.
- Further investigation may lead to novel antitumor drugs.
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