Survivin (BIRC5) Gene Polymorphism (rs9904341) Is Associated with Cancer Risk: A Meta-Analysis.

Area of Science:

• Genetics
• Oncology
• Molecular Biology

Background:

• Survivin (BIRC5) is an anti-apoptotic protein frequently overexpressed in various cancers.
• Elevated survivin levels correlate with adverse clinical outcomes in cancer patients.
• The -31G/C (rs9904341) polymorphism in the BIRC5 gene has been investigated for its association with cancer susceptibility.

Purpose of the Study:

• To conduct an updated meta-analysis evaluating the association between the survivin -31G/C (rs9904341) gene polymorphism and overall cancer risk.
• To assess the impact of this polymorphism across different genetic models and in specific ethnic groups.

Main Methods:

• A comprehensive literature search was performed using PubMed and Google Scholar.
• Data from 51 studies, including 10472 cases and 12193 controls, were pooled for meta-analysis.
• Statistical analyses, including sensitivity and risk of bias assessments, were conducted using RevMan 5.4 and Excel 2013.

Main Results:

• The meta-analysis revealed a significant association between the survivin -31G/C polymorphism and overall cancer risk across multiple genetic models (allelic, co-dominant, dominant, and recessive).
• Specifically, the C allele and CC genotype were associated with increased cancer risk.
• Stratified analysis indicated a significantly higher risk in the Asian population.

Conclusions:

• The -31G/C (rs9904341) polymorphism of the BIRC5 gene is associated with cancer risk, particularly in the Asian population.
• These findings highlight the potential role of this genetic variant in cancer susceptibility.
• Larger-scale clinical studies are recommended for further validation.