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A Method to Quantify Visual Information Processing in Children Using Eye Tracking
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Visual sensory and ocular motor function in children with polymicrogyria: relationship to magnetic resonance imaging

John P Kelly1, Gisele E Ishak2, James O Phillips3

  • 1Roger H. Johnson Vision Lab, Division of Ophthalmology, Seattle Children's Hospital, Seattle, Washington; Department of Ophthalmology, University of Washington Medical Center, Seattle.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|February 27, 2016
PubMed

Insights

Most children with polymicrogyria (PMG) have recordable visual function, but many do not improve over time. Seizures can impact visual acuity development in pediatric patients.

Area of Science:

  • Pediatric ophthalmology
  • Neuroscience
  • Developmental neurology

Background:

  • Polymicrogyria (PMG) is a cortical malformation affecting brain development.
  • Visual and ocular motor function can be impacted in children with PMG.
  • Understanding visual outcomes is crucial for managing pediatric neurological conditions.

Purpose of the Study:

  • To evaluate visual acuity and ocular motor function in children diagnosed with polymicrogyria (PMG).
  • To compare visual function in PMG patients with age-matched controls.
  • To identify factors influencing visual outcomes in pediatric PMG.

Main Methods:

  • Retrospective review of medical records for 15 children (0.4-4 years) with MRI-confirmed PMG.
  • Visual acuity assessed using Teller acuity cards.
  • Cortical function evaluated with pattern visually evoked potentials (VEP).
  • Ocular motor function assessed via video-oculography or clinical examination.

Main Results:

  • Visual acuity was normal in 5/15 children and subnormal in 10/15 (average 20/200).
  • Occipital lobe involvement in PMG significantly reduced VEP amplitude and signal-to-noise ratios.
  • Three infants with cytomegalovirus-related PMG showed preserved visual function despite MRI abnormalities.

Conclusions:

  • All children with PMG demonstrated recordable visual function (visual acuity or VEP).
  • Majority of patients did not show improvement in visual acuity over time; seizures may be a limiting factor.
  • Children with cytomegalovirus-related PMG can have normal visual acuity, even with developmental delay.
Abstract

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