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[Characteristics of long-term non-progressors and HIV controllers among HIV-infections in Henan, China]
1Institute for Prevention and Control of STD and AIDS, Henan Provincial Center for Diseases Control and Prevention, Zhengzhou 450016, China.
Insights
This study identified long-term non-progressors (LTNPs) and HIV controllers (HCs) in Henan, China. Findings highlight unique characteristics of these individuals, aiding further HIV research.
Area of Science:
- Immunology
- Virology
- Epidemiology
Background:
- Understanding long-term non-progressors (LTNPs) and HIV controllers (HCs) is crucial for advancing HIV/AIDS research.
- Identifying these distinct patient groups aids in developing targeted therapeutic and preventative strategies.
Purpose of the Study:
- To investigate the prevalence and specific characteristics of LTNPs and HCs within the HIV-infected population in Henan, China.
- To provide a detailed profile of these unique HIV-infected individuals.
Main Methods:
- Utilized data from HIV/AIDS prevention and control databases in Henan.
- Conducted investigations, verifications, sample collections, and correlation testing to identify and characterize LTNPs and HCs.
Main Results:
- Identified 148 LTNPs/HCs, with 71 individuals followed up.
- Demographic analysis revealed a majority were males over 40, Han nationality, farmers, infected via former plasma donation, and frequently co-infected with HCV.
- Median CD4 counts were 538 cells/μl and viral load was 3.14 log(10) copies/ml, with HIV controllers showing significantly lower viral loads.
Conclusions:
- The characteristics of LTNPs and HCs in Henan's HIV-infected population are noteworthy.
- Accurate classification of these individuals is essential for advancing future HIV research and understanding disease progression.
Objective:
To study the prevalence and characteristics of long-term non-progressors (LTNPs) and HIV controllers (HCs) among HIV-infections in Henan, China.
Methods:
Data in two databases (Information management system of HIV/AIDS prevention and control; HIV/AIDS testing application platform of Henan) were used to identify the LTNPs and HCs, investigation and verification, sample collection and correlation testing were carried out thereafter.
Results:
A total of 148 LTNPs/HCs were identified. Among them, 71 were followed up, including 58 LTNPs and 22 HCs, 12 cases were both LTNP and HC, 46 cases were LTNP but non-HC(LTNP+ HC-), 10 cases of HC but non-LTNP. Of the 71 individuals, 50 (70.4%) were males, 55 (77.5%) were older than 40 years of age, all belonged to Han nationality, 61 (85.9%) were farmers, 52 (73.2%) were infected through former plasma donation, 56 (78.9%) were-HCV positive. Median (interquartile range) of the CD4 counts was 538 (445-654) cell/μl and with virus load as 3.14 (2.03-3.82) log(10) copies/ml. The median viral load of HC was lower than that of LTNP + HC-(P=0.001).
Conclusion:
The characteristic of LTNPs and HCs in Henan HIV-infections were remarkable, more accurate classification of these cases was helpful to further research.
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