Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Performance outcomes of the PEDI-CAT for assessing functional ability in the population with leukodystrophy.

Developmental medicine and child neurology·2026

Same author

<i>PTPN1</i>-related autoinflammation is a common cause of Aicardi-Goutières Syndrome with reduced penetrance.

medRxiv : the preprint server for health sciences·2026

Same author

Clinically Important Endpoints in Individuals With Leukodystrophy: A Multisite Study.

Annals of the Child Neurology Society·2025

Same author

Clinical Characterization of a Multicenter International Cohort of Patients With Aicardi-Goutières Syndrome Homozygous for the RNASEH2B:p.Ala177Thr Variant: Early Clinical Markers of Disease Severity.

Pediatric neurology·2025

Same author

"What am I?" microbiology of culture-positive, biofire® blood culture identification 2 panel-negative bloodstream infections.

Diagnostic microbiology and infectious disease·2025

Same author

Reporting ABCD1 variants as actionable secondary findings on exome and genome sequencing.

Genetics in medicine : official journal of the American College of Medical Genetics·2025

Same journal

Exploring potential strategies to enhance memory and cognition in aging mice.

F1000Research·2026

Same journal

Construction an Implicit Block Multi-Steps Approach for Solving Sixth-Order Fractional Differential Equations.

F1000Research·2026

Same journal

Kansei Engineering in the Evolving Service Sector: A Decade of Insights.

F1000Research·2026

Same journal

A Safety-First Mindset: Role of Patient Safety Culture in Enhancing Healthcare Workers' Emotional Intelligence.

F1000Research·2026

Same journal

Decoding Decisions: Personality-Interest Motivational Sequences as Predictors of Career Paths.

F1000Research·2026

Same journal

Beyond the Transparent Barrier: A Domain Visualization and Integrative Review of Contemporary Research on Gender-Based Professional Stasis.

F1000Research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 25, 2026

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Progressive Multifocal Leukoencephalopathy.

Laura Adang¹, Joseph Berger²

¹Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA.

|February 27, 2016

Summary

This summary is machine-generated.

Progressive multifocal leukoencephalopathy (PML) is a severe brain disease caused by the JC virus (JCV). Currently, there are no effective treatments for PML, highlighting a critical unmet medical need.

Keywords:

JC virus Progressive multifocal leukoencephalopathy demyelination highly active antiretroviral therapy immunocompromised

More Related Videos

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

Related Experiment Videos

Last Updated: Mar 25, 2026

Mouse Models of Periventricular Leukomalacia

Mouse Models of Periventricular Leukomalacia

Published on: May 18, 2010

Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

Area of Science:

Neuroscience
Virology
Immunology

Background:

Progressive multifocal leukoencephalopathy (PML) is a severe, often fatal, demyelinating disease.
PML is associated with compromised cell-mediated immunity, including HIV infection and immunosuppressive therapies.
The JC virus (JCV), a common polyomavirus, is the causative agent of PML.

Purpose of the Study:

To review the current understanding of PML pathogenesis and clinical presentation.
To discuss the challenges in developing effective therapies for PML.
To highlight the need for targeted treatments for this devastating neurological condition.

Main Methods:

Literature review of PML studies.
Analysis of JCV pathogenesis and host immune responses.
Synthesis of clinical data and treatment outcomes.

Main Results:

JCV infects and replicates in oligodendrocytes and astrocytes in the brain.
Demyelination and neurological deficits result from JCV-induced cell death.
No consistently effective targeted therapies for PML have been identified.

Conclusions:

PML remains a significant cause of morbidity and mortality due to JCV infection.
Restoring immune function and supportive care are current management strategies.
Further research is crucial for developing effective treatments against JCV and PML.