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Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

10
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
10

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Recent advances in understanding dengue.

Sophie Yacoub1, Juthathip Mongkolsapaya2, Gavin Screaton3

  • 1Department of medicine, Imperial College London, London, UK; Oxford University Clinical research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.

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|February 27, 2016
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Summary
This summary is machine-generated.

Dengue incidence is rising globally, with severe cases involving capillary leak and organ impairment. This review covers dengue pandemic drivers, pathogenesis, and recent clinical trial findings for therapeutics and vaccines.

Keywords:
Flavivirusdenguedengue virus

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Area of Science:

  • * Infectious Diseases
  • * Virology
  • * Epidemiology

Background:

  • * Dengue virus (DENV) poses a significant global health threat, with a four-fold increase in incidence over the past two decades.
  • * DENV infection presents a spectrum of illness, ranging from mild febrile illness to severe dengue characterized by capillary leak, coagulopathy, and organ impairment.
  • * The pathogenesis of severe dengue is not fully understood but is believed to involve immune-mediated mechanisms.

Purpose of the Study:

  • * To review recent advances in dengue research.
  • * To discuss the drivers of the global dengue pandemic.
  • * To explore viral structure, pathogenesis of severe disease, and findings from recent clinical trials on therapeutics and vaccines.

Main Methods:

  • * Comprehensive literature review of recent dengue research.
  • * Analysis of epidemiological trends and risk factors for severe dengue.
  • * Evaluation of clinical trial data for dengue therapeutics and vaccines.

Main Results:

  • * The review synthesizes current knowledge on dengue epidemiology, viral characteristics, and severe disease pathogenesis.
  • * Recent clinical trials show promising results for novel dengue therapeutics and vaccines.
  • * Understanding of immune-mediated mechanisms in severe dengue pathogenesis is evolving.

Conclusions:

  • * Continued research is crucial to address the growing global dengue pandemic.
  • * Development of effective therapeutics and vaccines remains a priority.
  • * Integrated dengue control strategies are essential for public health.