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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...

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Updated: Mar 25, 2026

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Nanoengineered Platforms to Guide Pluripotent Stem Cell Fate.

Katy Rutledge¹, Ehsan Jabbarzadeh²

¹Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, USA.

Journal of Nanomedicine & Nanotechnology

|February 27, 2016

Summary

This review explores how nanoscale platforms and extracellular matrix (ECM) features guide pluripotent stem cells (PSCs). Understanding these interactions is key for advancing tissue engineering and regenerative medicine.

Keywords:

Cell shape Embryonic stem cells Induced pluripotent stem cells Nanotechnology Physical signals Stem cell microenvironment Surface topography

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Last Updated: Mar 25, 2026

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Published on: August 29, 2020

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Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Published on: January 18, 2020

Area of Science:

Biomaterials Science
Stem Cell Biology
Tissue Engineering

Background:

Tissue engineering aims to repair organs using cells, signaling molecules, and scaffolds.
Pluripotent stem cells (PSCs) offer a promising cell source for regenerative medicine due to their self-renewal and differentiation potential.
The cellular microenvironment, including physical and chemical cues, significantly influences stem cell behavior and lineage commitment.

Purpose of the Study:

To investigate nanoscale platforms for tissue engineering applications.
To explore the use of nanotechnologies in directing pluripotent stem cell (PSC) lineage determination.
To understand the interplay between physical and chemical signals in regulating cellular fate.

Main Methods:

Review of current literature on nanoscale platforms in tissue engineering.
Analysis of how extracellular matrix (ECM) nanoarchitecture influences stem cell behavior.
Investigation of nanotechnologies for controlling PSC differentiation.

Main Results:

Nanoscale features of the extracellular matrix (ECM) impact cell adhesion, migration, proliferation, and lineage commitment.
Physical cues, alongside chemical factors, play a crucial role in stem cell fate determination.
Significant advances have been made in understanding nanoscale cue interactions with stem cells, but further research is needed.

Conclusions:

Nanoscale platforms are critical for recapitulating the in vivo microenvironment in vitro.
Nanotechnology offers powerful tools for directing pluripotent stem cell (PSC) differentiation for tissue engineering.
Further research into the combined effects of physical and chemical cues at the nanoscale is essential for advancing regenerative medicine.