Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lymphocyte stimulation by cell wall constituents.

¹Max Planck Society, Clinical Research Unit for Rheumatology/Immunology, University Erlangen-Nürnberg, Federal Republic of Germany.

Rheumatology International

|January 1, 1989

Summary

T cells typically recognize peptide antigens. This study found that human T cells did not respond to the group-specific carbohydrate of A streptococci, suggesting they recognize other structures on the bacteria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human T-cell clones find ever wider application.

Immunology today·2014

Same author

Neuronal hypoxia: protective effects of mononuclear cord blood cells after direct and indirect application.

Journal of stem cells & regenerative medicine·2014

Same author

Visualizing inflammation activity in rheumatoid arthritis with Tc-99 m anti-CD4-mAb fragment scintigraphy.

Nuclear medicine and biology·2014

Same author

First- and second-line anti-tuberculosis drug resistance in Northwest Ethiopia.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2012

Same author

Clinical impact of radiolabeled anti-CD4 antibodies in the diagnosis of rheumatoid arthritis.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2011

Same author

A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia.

Cell proliferation·2009

Area of Science:

Immunology
Microbial Pathogenesis

Background:

T cells are crucial for adaptive immunity, recognizing peptide antigens presented by MHC molecules.
The ability of T cells to recognize carbohydrate antigens remains largely unexplored.
Streptococcus pyogenes (Group A Strep) is a significant human pathogen.

Purpose of the Study:

To investigate the human T cell immune response to the group-specific carbohydrate antigen of A streptococci.
To determine if T cells can recognize carbohydrate antigens directly.

Main Methods:

Utilized T cell lines and clones specific for Streptococcus pyogenes.
Assessed T cell proliferation in response to purified group-specific carbohydrate antigen.
Investigated T cell response after periodate treatment to remove carbohydrate structures.

Main Results:

The group-specific carbohydrate of A streptococci effectively stimulated B cells to produce antibodies.
However, this carbohydrate antigen failed to induce proliferation in T cells specific for Streptococcus pyogenes.
T cell stimulation persisted even after periodate treatment, indicating recognition of non-carbohydrate components.

Conclusions:

Human T cells specific for Streptococcus pyogenes do not appear to recognize the group-specific carbohydrate antigen.
These T cells likely recognize peptide or other non-carbohydrate structures on the streptococcal surface.
This highlights the specificity of T cell recognition and suggests limitations in their ability to respond to carbohydrate antigens in this context.

Related Experiment Videos