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Updated: Mar 25, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
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Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1

Sora Kwon1, Ji-Sook Jeon1, Su Bin Kim1

  • 1Department of Pharmaceutical Engineering, Hoseo University, Asan, 336-795, Republic of Korea.

Lipids in Health and Disease
|February 29, 2016
PubMed
Summary

Rapamycin increases triglycerides by reducing Prox1 expression in liver cells. This study reveals a new mechanism linking mTOR signaling to lipid metabolism via Prox1 regulation.

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