Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Toxidromes: Clinical Features

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Nonconscious Mimicry

Nonconscious Mimicry

Nonconscious mimicry occurs when individuals alter their mannerisms to match the behaviors and expressions of those nearby, without intention.

Allergic Reactions

Allergic Reactions

Adrenergic Agonists: Direct-Acting Agents

Adrenergic Agonists: Direct-Acting Agents

Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Establishing a core outcome measure for cancer in trials in kidney transplantation: a standardized outcomes in nephrology-kidney transplantation consensus workshop report.

Transplant international : official journal of the European Society for Organ Transplantation·2026

Same author

Deceased Organ Donation and Transplantation in LIMC: A Meeting Report.

Transplantation·2026

Same author

Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study.

American journal of clinical dermatology·2026

Same author

A school-based respect-for-life program integrating deceased organ donation awareness in South Korea: a post-class mixed-methods evaluation.

Scientific reports·2026

Same author

Critically Important Cancer Outcomes to Report in Kidney Transplant Trials.

Kidney international reports·2025

Same author

Associations of Skeletal Muscle Mass and Body Mass Index With Clinical Outcomes in Autosomal-Dominant Polycystic Kidney Disease: An Observational Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2025

Same journal

Anaphylaxis: State-of-the-Art.

Immunology and allergy clinics of North America·2026

Same journal

Upending Impending Doom.

Immunology and allergy clinics of North America·2026

Same journal

Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.

Immunology and allergy clinics of North America·2026

Same journal

Emerging Therapies for Anaphylaxis.

Immunology and allergy clinics of North America·2026

Same journal

Novel Epinephrine Delivery Devices.

Immunology and allergy clinics of North America·2026

Same journal

Venom Anaphylaxis.

Immunology and allergy clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 5, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast Cell Activation Syndrome and Mimickers.

Curie Ahn¹, César Alberto Galván Calle², Jonathan A Bernstein³

¹Department of Medicine, Westchester Medical Center, New York Medical College, 100 Woods Road, Valhalla, NY 10595, USA.

Immunology and Allergy Clinics of North America

|April 3, 2026

Summary

This summary is machine-generated.

Mast cell activation syndrome (MCAS) is a complex condition that often leaves patients feeling unheard by clinicians. Accurate patient characterization, including ruling out mimicking conditions, is crucial for effective MCAS management.

Keywords:

Dysautonomia Hereditary alpha tryptasemia Mast cell activation syndrome Neuroimmunology Postural orthostatic tachycardia syndrome Systemic mastocytosis

More Related Videos

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Related Experiment Videos

Last Updated: Apr 5, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

Allergy and Immunology
Clinical Medicine

Background:

Mast cell activation syndrome (MCAS) is a prevalent but challenging condition managed by allergists-immunologists.
Patients frequently report feeling dismissed, leading to fragmented care and multiple specialist visits.
Accurate diagnosis and characterization are essential for optimal patient outcomes.

Purpose of the Study:

To highlight the challenges in diagnosing and managing MCAS.
To emphasize the importance of accurate patient assessment in MCAS care.
To guide clinicians in providing consistent and compassionate care for MCAS patients.

Main Methods:

Review of clinical presentation and diagnostic considerations in MCAS.
Discussion of coexisting conditions that mimic or confound MCAS diagnosis.
Analysis of patient experiences and healthcare-seeking behaviors.

Main Results:

MCAS diagnosis is often complicated by its varied presentation and overlapping symptoms with other conditions.
Patients often experience significant delays in diagnosis and treatment due to feeling unheard.
Identifying and addressing confounding conditions is key to successful MCAS management.

Conclusions:

Clinicians require enhanced strategies to effectively diagnose and manage MCAS.
A thorough patient evaluation, including assessment for mimicking conditions, is paramount.
Improving patient communication and care coordination can significantly enhance outcomes for individuals with MCAS.