Related Experiment Video
Updated: Mar 25, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.9K
Systemic therapy for metastatic bladder cancer in 2016 and beyond
Ana Collazo-Lorduy1,2, Matthew D Galsky3
1Icahn School of Medicine at Mount Sinai, Department of Pathology, 1 Gustave L Levy Place, New York, NY 10029, USA.
Future Oncology (London, England)
|March 1, 2016
Summary
Metastatic urothelial cancer treatment is challenging due to chemotherapy resistance. Innovative therapies targeting genetic alterations, tumor vasculature, and immune escape offer new hope for patients with platinum-resistant disease.
Area of Science:
- Oncology
- Urothelial Carcinoma Research
- Cancer Therapeutics
Background:
- Metastatic urothelial cancer typically has poor outcomes.
- Platinum-based chemotherapy is standard first-line treatment but often leads to resistance and disease progression.
- Few FDA-approved therapies exist for platinum-resistant metastatic urothelial cancer.
Purpose of the Study:
- To review novel therapeutic strategies for metastatic urothelial cancer.
- To focus on emerging treatments for platinum-resistant disease.
- To highlight advancements in three key therapeutic areas.
Main Methods:
- Review of recent clinical trials and preliminary results.
- Focus on innovative therapeutic approaches.
- Analysis of targeted therapies for specific cancer mechanisms.
Main Results:
- Preliminary results from recent trials suggest significant progress.
- Innovative approaches are emerging as potential game-changers.
- Therapeutic targets include recurrent somatic alterations, tumor neovasculature, and immune escape.
Conclusions:
- A paradigm shift in managing metastatic urothelial cancer is anticipated.
- New treatment avenues are becoming available for platinum-resistant cases.
- Targeting specific molecular and immunological pathways holds promise.
Related Concept Videos
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K
01:27Tumor Immunotherapy
2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
02:49Cancer Therapies
10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K