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Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs.
O Salomó-Coll1, J E Val de Maté-Sánchez2, M P Ramírez-Fernandez2
1Department of Oral and Maxillofacial Surgery, International University of Catalonia (UIC), Barcelona, Spain.
Clinical Oral Implants Research
|March 1, 2016
Summary
Topical melatonin and vitamin D applications enhanced osseointegration of immediate dental implants in dogs. Both treatments improved bone formation and reduced bone loss around implants after 12 weeks.
Area of Science:
- Dental Implantology
- Biomaterials Science
- Oral Surgery
Background:
- Osseointegration is crucial for dental implant success.
- Immediate implant placement offers advantages but requires robust osseointegration.
- Topical agents may enhance bone healing and implant stability.
Purpose of the Study:
- To evaluate the effects of topical melatonin versus vitamin D on osseointegration of immediate implants.
- To compare bone-to-implant contact (BIC), new bone formation (NBF), and crestal bone loss (CBL) between treatment groups.
Main Methods:
- Six dogs received immediate implants in extracted premolar sites.
- Three groups were formed: 5% melatonin (MI), 10% vitamin D (DI), and control (CI).
- Histological analysis assessed BIC, NBF, inter-thread bone, and linear measurements at 12 weeks.
Main Results:
- All implants showed clinical stability and histological osseointegration.
- Melatonin and vitamin D groups showed significantly higher peri-implant new bone formation compared to control.
- Melatonin significantly reduced lingual crestal bone loss, while vitamin D significantly reduced buccal crestal bone loss.
Conclusions:
- Topical melatonin and vitamin D significantly improve bone formation around immediate implants.
- Both agents aid in reducing crestal bone loss following implant placement.
- These findings suggest potential benefits of topical melatonin and vitamin D in enhancing dental implant osseointegration.
