[Disorders of interleukin cascade reactions in pemphigus and pemphigoid and methods for their correction]

The epidermal keratinocyte (EK) culture supernatant from patients with pemphigus vulgaris and bullous pemphigoid in the acute phase of the disease depressed the lymphocyte blastogenesis with phytohemagglutinin and conA, interleukin-1 (IL-1) and interleukin-2 (IL-2) production, and the expression of receptors to IL-2 by donor peripheral blood mononuclears. During remission EK recovered their ability to stimulate the immunocompetent cell functional activity. Addition of pemphigus and pemphigoid antibodies to normal human EK culture resulted in the emergence of immune reaction suppressing factors in the supernatant. Reduction of the lymphocyte functional activity, induced by patients' antibody-transformed EK, normalized after blood adsorption on carbon hemocarbosorbents. IL-1 and IL-2 inhibitors have been detected in eluates from sorbents.