Temporal variation in the distribution of type-1 human astrovirus lineages in a settled population over 14 years
Related Experiment Video
Updated: Mar 25, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Simona De Grazia1, Floriana Bonura2, Krisztián Bányai3
1Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, via del Vespro 133, 90127, Palermo, Italy. simona.degrazia@unipa.it.
Abstract:
Human astroviruses (HAstVs) are important enteric pathogens that are genetically and antigenically heterogeneous and can be classified into eight sero/genotypes (HAstV-1 to -8) and different lineages within each HAstV type. This study describes the genetic diversity of HAstVs circulating in southern Italy over 14 years. Molecular analysis of HAstV-1 strains showed that three different lineages (1a, 1b and 1d) of the predominant genotype were circulating during the study period. The study of an archival collection of HAstV strains offers a unique opportunity to evaluate the patterns of variation of HAstV infections over the years and to correlate the observed epidemiological changes to the genetic variability of HAstVs.
Related Concept Videos
Human Virome
Viral Mutations
Infectious Diseases and Their Occurrence
Viruses of Archaea
Viral Recombination

