Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.5K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.5K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.0K
4.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Culture01:17

Stem Cell Culture

6.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical, legal, and social issues associated with human fetal tissue research in Japan.

Regenerative medicine·2026
Same author

Embryonic lineage-specific iPSC-derived mesenchymal stem/stromal cells exhibit different morphologies and intrinsic functions.

iScience·2026
Same author

Transitioning from human primordial germ cells to embryonic germ cells.

Stem cell reports·2025
Same author

Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans.

Stem cell reports·2025
Same author

Morula-derived trophectoderm stem cells.

Nature cell biology·2025
Same author

Characterization of Gene Expression Suppression by Bovine Coronavirus Non-Structural Protein 1.

Viruses·2025

Related Experiment Video

Updated: Mar 25, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.4K

[Application for Lifestyle disease by iPS cells technologies].

Yasuhiro Takashima1

  • 1Department of Life Science Frontiers, CiRA, Kyoto University, Japan.

Clinical Calcium
|March 1, 2016
PubMed
Summary

Induced pluripotent stem cells (iPS cells) show promise for studying lifestyle diseases, particularly obesity. Researchers established differentiation protocols for adipocytes from iPS cells, highlighting naive PSCs as ideal for this process.

Area of Science:

  • Stem Cell Biology
  • Metabolic Disease Research

Context:

  • Lifestyle diseases, including obesity, diabetes, and cardiovascular conditions, present complex pathologies.
  • Current understanding of lifestyle disease pathology using induced pluripotent stem cells (iPS cells) is limited.
  • Existing research often prioritizes regenerative medicine applications, such as beta-cell therapy for type 2 diabetes.

Purpose:

  • To investigate the potential of iPS cells in understanding lifestyle disease pathology, focusing on adipogenesis.
  • To establish and analyze differentiation protocols for adipocytes from mouse embryonic stem cells (ES cells) and human iPS cells.
  • To evaluate the suitability of different pluripotent stem cell types for differentiation.

Summary:

  • Established differentiation protocols for adipocytes from mouse ES cells and human iPS cells.

More Related Videos

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.8K
Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10:30

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Published on: August 4, 2022

3.7K

Related Experiment Videos

Last Updated: Mar 25, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
08:00

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

32.4K
Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery
12:40

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

10.8K
Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
10:30

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Published on: August 4, 2022

3.7K
  • Investigated adipogenesis from iPS cells as a model for studying obesity, a key factor in lifestyle diseases.
  • Introduced novel naive human pluripotent stem cells ('Reset cells') as superior starting material for differentiation due to their hypomethylated state and early developmental stage.

    • Impact:

    • Provides a foundation for using iPS cell technology to model and understand the complex mechanisms of lifestyle diseases.
    • Offers optimized protocols for generating adipocytes, crucial for metabolic research.
    • Highlights the advantages of naive pluripotent stem cells for enhanced differentiation efficiency and quality in disease modeling.