Related Experiment Video
Updated: Mar 25, 2026

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
Fabrication of biodegradable PEG-PLA nanospheres for solubility, stabilization, and delivery of curcumin
Hongying Liang1, Joel M Friedman1, Parimala Nacharaju1
1a Department of Physiology & Biophysics , Albert Einstein College of Medicine , Bronx , NY , USA.
Abstract:
Curcumin is an effective and safe anticancer agent, and also known to induce vasodilation, but its hydrophobicity limits its clinical application. In this study, a simple emulsion method was developed to prepare biodegradable poly (ethylene glycol)-poly (lactic acid) (PEG-PLA) nanospheres to encapsulate curcumin to improve its solubility and stability. The nanoparticle size was around 150 nm with a narrow size distribution. Fluorescence microscopy showed that curcumin encapsulated PEG-PLA nanospheres were taken up rapidly by Hela and MDA-MB-231 cancer cells. This novel nanoparticulate carrier may improve the bioavailability of curcumin without affecting its anticancer properties.
Related Concept Videos
Bioplastics
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

