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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Polymeric materials for embolic and chemoembolic applications.

Azadeh Poursaid1, Mark Martin Jensen1, Eugene Huo2

  • 1Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA; Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84112, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 1, 2016
PubMed
Summary
This summary is machine-generated.

Embolization materials, or embolics, are used to block blood vessels. This review covers current polymeric embolics and novel materials like tunable microspheres and in situ gelling agents for improved medical procedures.

Keywords:
Arteriovenous malformationsDrug eluting beadsEmbolicsHepatocellular carcinomaPolymersUterine fibroids

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Area of Science:

  • Biomaterials Science
  • Interventional Radiology
  • Polymer Chemistry

Background:

  • Percutaneous transcatheter embolization is a medical procedure to occlude blood vessels.
  • Embolic materials are crucial for this procedure, with properties affecting efficacy and safety.
  • Existing embolics include gelatin foam and poly(vinyl alcohol).

Purpose of the Study:

  • To review currently available embolic materials for embolization.
  • To discuss novel polymeric embolics under investigation.
  • To highlight advancements in embolic agent characteristics.

Main Methods:

  • Literature review of commercially available embolic agents.
  • Analysis of research on investigational polymeric embolics.
  • Categorization of embolics by material composition and properties.

Main Results:

  • Commercially available polymeric embolics include gelatin foam and synthetic polymers like poly(vinyl alcohol).
  • Investigational materials include tunable, bioresorbable microspheres (chitosan, poly(ethylene glycol) derivatives), in situ gelling liquid embolics, and radiopaque embolics.
  • Embolic materials vary in chemical composition, mechanical properties, and drug-delivery capabilities.

Conclusions:

  • A range of polymeric embolics are available for clinical use.
  • Emerging embolic technologies offer potential for improved safety and efficacy.
  • Future developments focus on tailored material properties and enhanced in vivo performance.