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Survivin Modulators: An Updated Patent Review (2011-2015)
Kislay Roy, Neha Singh, Rupinder K Kanwar
1Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), Centre for Molecular and Medical Research (C-MMR), School of Medicine (SoM), Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, Australia. jagat.kanwar@deakin.edu.au.
Recent Patents on Anti-Cancer Drug Discovery
|March 1, 2016
Summary
Survivin, a protein linked to poor cancer survival, is a promising therapeutic target. Recent innovations focus on natural compounds like peptides and oligonucleotides over synthetic drugs for anti-survivin therapies.
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Survivin is overexpressed in many cancers, correlating with poor patient survival.
- Existing survivin-targeting therapeutics have shown limited success in clinical trials.
- Recent therapeutic innovations offer new strategies to target survivin.
Purpose of the Study:
- To provide an update on current and emerging therapeutic strategies targeting survivin.
- To highlight recent patents related to survivin-targeted therapies.
- To offer insights into survivin's role in cancer progression and drug resistance.
Main Methods:
- Comprehensive review of recent patents on anti-survivin therapies.
- Analysis of therapeutic strategies including quantification, immunotherapeutics, promoter applications, RNA interference, small molecule inhibitors, and nanoparticles.
- Inclusion of survivin-targeted therapeutics in clinical stages.
Main Results:
- Gataparsen identified as the most utilized agent in clinical trials for anti-survivin therapy.
- Recent patents predominantly focus on natural anti-survivin therapeutics.
- Natural compounds like peptides and antisense oligonucleotides show a trend over synthetic drugs.
Conclusions:
- Preclinical anti-survivin therapies are evolving, with gataparsen showing clinical utility.
- A shift towards natural anti-survivin therapeutics (peptides, oligonucleotides) is evident in recent patent literature.
- Natural therapeutic agents are gaining prominence over synthetic drugs in survivin-targeted cancer therapy.
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