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[Conditionally pathogenic microorganisms in patients with bisphosphonate jaw osteonecrosis]
T P Ivaniushko1, K A Poliakov1, Iu A Medvedev1
1I.M. Sechenov First Moscow State Medical University, Moscow, Russia; DNA-Technology LTD, Moscow, Russia; State Research Center Institute of Immunology, Moscow, Russia.
Stomatologiia
|March 2, 2016
Summary
This study highlights the significant role of oral microorganisms in bisphosphonate-induced osteonecrosis of the facial bones. Surgical treatment offers effective long-term rehabilitation for patients with this condition.
Area of Science:
- Oral and Maxillofacial Surgery
- Microbiology
- Oncology
Background:
- Bisphosphonate-induced osteonecrosis (BRONJ) of the jaw is a serious complication.
- Understanding the microbial role in BRONJ is crucial for treatment strategies.
Observation:
- Analyzed three clinical cases of bisphosphonate osteonecrosis of the facial bones.
- Identified 15 conditionally pathogenic oral microorganisms using real-time PCR in saliva, wound, and bone samples.
- Compared findings with purulent-inflammatory diseases of the maxillofacial area.
Findings:
- Conditionally pathogenic oral microorganisms play a significant role in the development of facial bone osteonecrosis.
- A wide range of bacterial species were identified in patients with osteonecrosis.
- Bone tissue is highly susceptible to microbial colonization.
Implications:
- Defines treatment strategies for bisphosphonate-induced osteonecrosis of the facial bones.
- Highlights the importance of microbial assessment in BRONJ management.
- Surgical treatment leads to effective long-term patient rehabilitation.
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