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High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
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Analysis of Forensic Casework Utilizing Infrared Spectroscopic Imaging.
1FDA Forensic Chemistry Center, Cincinnati, OH 45237, USA. adam.lanzarotta@fda.hhs.gov.
Sensors (Basel, Switzerland)
|March 2, 2016
Summary
Fourier transform infrared (FT-IR) spectroscopic imaging is a novel technique for forensic analysis. This study showcases its application in diverse forensic casework, including drug analysis and adulteration detection.
Area of Science:
- Analytical Chemistry
- Forensic Science
- Spectroscopy
Background:
- Fourier transform infrared (FT-IR) spectroscopic imaging is an emerging analytical technique.
- Its application in forensic casework is not yet widespread due to instrument novelty.
- Limited studies document its use in forensic laboratories.
Purpose of the Study:
- To demonstrate the utility of FT-IR spectroscopic imaging in forensic casework.
- To analyze diverse multi-component samples relevant to forensic investigations.
- To highlight the capabilities of FT-IR imaging for compositional analysis.
Main Methods:
- Utilized Fourier transform infrared (FT-IR) spectroscopic imaging.
- Applied the technique to various forensic sample types.
- Performed compositional analysis on multi-component samples.
Main Results:
- Successfully analyzed animal tissue sections for toxic inclusions.
- Determined the composition of drugs and dietary supplements.
- Identified different salt forms of an active pharmaceutical ingredient (API).
- Analyzed adulterated bulk API and unknown trace powders for illicit drugs.
- Detected bleach adulteration in an ophthalmic solution.
Conclusions:
- FT-IR spectroscopic imaging is a versatile tool for forensic analysis.
- The technique can effectively analyze complex forensic samples.
- FT-IR imaging aids in identifying adulterants and determining sample composition in casework.
Keywords:
adulterationdietary supplementforensic scienceinfrared spectroscopic imagingmelamine cyanurateMore Related Videos
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