Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.0K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

92
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
92
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

424
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
424
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

106
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
106

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparation and Optimization of Voriconazole Gel 0.25% for Topical Delivery in Terbinafine Resistance Dermatophytosis: In Vitro and Pilot Animal Study.

Dermatology research and practice·2026
Same author

Localized nasal porokeratosis successfully treated with 5-fluorouracil and calcipotriene.

JAAD case reports·2026
Same author

Human LFA-1 governs T cell immune surveillance of the skin.

Science immunology·2026
Same author

Response to the Letter to the Editor: Unlocking Better Keloid Treatment: Corticosteroid, 5-Fluorouracil, and Hyaluronidase vs. Corticosteroid Alone: A Randomized Comparative Study.

Health science reports·2026
Same author

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in <i>Candida</i> Species Isolated From Diaper Rash of Neonates.

Health science reports·2026
Same author

Knowledge, Attitudes and Practice of Iranian Patients on Sunscreen Application.

Journal of cosmetic dermatology·2025

Related Experiment Video

Updated: Mar 24, 2026

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

13.1K

Nano-Sized Technologies for Miconazole Skin Delivery.

Alireza Firooz, Roshanak Namdar, Shohreh Nafisi1

  • 1Department of Dermatology, University of California, San Francisco, CA, USA. drshnafisi@gmail.com.

Current Pharmaceutical Biotechnology
|March 2, 2016
PubMed
Summary

Novel nano-formulations enhance miconazole nitrate

Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Dermatology

Background:

  • Miconazole nitrate, an antifungal, has poor skin penetration, limiting its efficacy for deep fungal infections.
  • Topical drug delivery faces challenges due to skin's natural barriers.
  • Nanoparticle-based drug delivery offers a promising solution for enhanced topical treatments.

Purpose of the Study:

  • To review advanced nano-based formulation strategies for improving miconazole skin delivery.
  • To highlight the potential of nanoparticles in overcoming skin penetration barriers for antifungal drugs.
  • To focus on novel approaches enhancing miconazole permeation for treating fungal skin infections.

Main Methods:

  • Review of recent scientific literature on nano-formulations for miconazole.

More Related Videos

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K
Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device
06:02

Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device

Published on: March 22, 2022

10.9K

Related Experiment Videos

Last Updated: Mar 24, 2026

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

13.1K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.1K
Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device
06:02

Production of siRNA-Loaded Lipid Nanoparticles using a Microfluidic Device

Published on: March 22, 2022

10.9K
  • Analysis of various nanoparticle systems including ethosomes, liposomes, SLNs, and NLCs.
  • Examination of studies focusing on controlled release, retention, and permeation enhancement.

    • Main Results:

    • Nanoparticle encapsulation (ethosomes, liposomes, SLNs, NLCs) can significantly improve miconazole skin penetration.
    • Nano-formulations facilitate localized drug delivery and enhance drug retention in the skin.
    • Recent research demonstrates improved efficacy of miconazole via nano-based delivery systems.

    Conclusions:

    • Nano-based strategies are effective in overcoming the poor skin penetration of miconazole nitrate.
    • Advanced nano-formulations represent a significant advancement in topical antifungal drug delivery.
    • Further development of these nano-approaches holds great potential for treating deep-seated fungal skin infections.