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Updated: Mar 24, 2026
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Myostatin as a Marker for Doxorubicin Induced Cardiac Damage
Vural Kesik1, Tevfik Honca2, Mustafa Gulgun3
1Departments of Pediatric Oncology, Gulhane Military Medical Academy, Ankara, Turkey.
Purpose:
Doxorubicin (DXR) is an effective chemotherapeutic agent but causes severe cardiac failure over known doses. Thus, early detection and prevention of cardiac damage is important. Various markers have been tested for early detection of cardiac damage. Myostatin is a protein produced in skeletal muscle cells inhibits muscle differentiation and growth during myogenesis.
Methods:
We evaluated the role of myostatin as a marker for showing DXR induced cardiac damage and compared with well known cardiac markers like NT-proBNP, hs-TnT and CK in a rat model of chronic DXR cardiotoxicity.
Results:
Myostatin, NT-proBNP, and hs-TnT but not CK rose significantly during DXR treatment.
Conclusion:
Myostatin can be used as an early marker of DXR induced cardiotoxicity.
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