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The relationship between brucellosis and vitamin D.
Behice Kurtaran1, Ozay Akyildiz, Aslihan Candevir Ulu
1Cukurova University Medical Faculty, Adana, Turkey. behicekurtaran@gmail.com.
Journal of Infection in Developing Countries
|March 2, 2016
Summary
Vitamin D and vitamin D receptor (VDR) levels are lower in patients with brucellosis before treatment. These findings suggest vitamin D plays a role in brucellosis pathogenesis.
Area of Science:
- Infectious Diseases
- Immunology
- Endocrinology
Background:
- Brucellosis is a common infection in Turkey.
- The cellular immune system is crucial in brucellosis progression.
- The relationship between vitamin D, soluble vitamin D receptor (VDR), and brucellosis requires further investigation.
Purpose of the Study:
- To determine the association between vitamin D and soluble VDR levels in patients diagnosed with brucellosis.
- To compare these levels in patients with healthy controls.
Main Methods:
- A case-control study was conducted with 86 brucellosis patients and healthy controls.
- Vitamin D and soluble VDR levels were measured before treatment.
- Clinical findings and laboratory parameters were recorded.
Main Results:
- Brucellosis patients exhibited significantly lower vitamin D and VDR levels compared to the control group.
- Lower levels were observed in males with brucellosis versus male controls.
- VDR levels were higher in males than females within the patient group.
Conclusions:
- Pre-treatment vitamin D and VDR levels are significantly reduced in brucellosis patients.
- These findings indicate a potential role for vitamin D in the pathogenesis of brucellosis.
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