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Related Experiment Videos

Is diazepam an antidepressant?

J W Tiller1, I Schweitzer, K P Maguire

  • 1Department of Psychiatry, Univerisity of Melbourne.

The British Journal of Psychiatry : the Journal of Mental Science
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

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Diazepam showed antidepressant effects in atypical depression, initially outperforming moclobemide. Benzodiazepines warrant further study for their potential antidepressant actions.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Atypical depression is a subtype of depression with distinct clinical features.
  • The efficacy of benzodiazepines as antidepressants is not well-established.

Purpose of the Study:

  • To compare the antidepressant efficacy of diazepam with moclobemide in patients with atypical depression.
  • To investigate the potential antidepressant properties of benzodiazepines.

Main Methods:

  • A double-blind, sequential study design was employed.
  • Patients with atypical depression were treated with either diazepam or moclobemide.
  • Depression ratings were assessed over an eight-week treatment period.

Main Results:

  • Both diazepam and moclobemide significantly improved depression ratings over eight weeks.

Related Experiment Videos

  • Diazepam demonstrated significantly better antidepressant effects than moclobemide at the four-week mark.
  • No withdrawal reactions were reported by patients discontinuing diazepam within one year.

    • Conclusions:

    • Diazepam exhibits antidepressant properties in patients with atypical depression.
    • These findings suggest that benzodiazepines may warrant reconsideration as potential antidepressants.
    • Further research into the antidepressant mechanisms of benzodiazepines is indicated.