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Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay
Published on: October 2, 2017
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Olfactory receptor signaling
Gabriela Antunes1, Fabio Marques Simoes de Souza2
1Laboratory of Neural Systems (SisNE), Department of Physics, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Methods in Cell Biology
|March 2, 2016
Summary
This chapter provides an overview of olfactory receptor signaling, detailing recent advances in understanding how the sense of smell functions at a molecular level. It covers the large family of odorant receptors (ORs) involved in scent detection.
Area of Science:
- Molecular Biology
- Neuroscience
- Biochemistry
Background:
- G protein-coupled receptors (GPCRs) are the largest membrane protein family in the human genome.
- Odorant receptors (ORs) constitute over half of all GPCRs and are crucial for olfaction.
- Nobel laureates Buck and Axel laid the groundwork for understanding odor recognition mechanisms.
Purpose of the Study:
- To provide a comprehensive overview of olfactory receptor signaling pathways.
- To review recent scientific advancements in the field of olfaction.
- To consolidate current knowledge on the molecular basis of smell.
Main Methods:
- Literature review of olfactory receptor signaling.
- Analysis of recent research on odorant receptor function.
- Synthesis of findings on the molecular mechanisms of smell.
Main Results:
- Significant progress has been made in unraveling the complexities of the sense of smell.
- The chapter highlights key discoveries in olfactory receptor signaling.
- Recent advances expand our understanding of odor recognition.
Conclusions:
- Olfactory receptor signaling is a complex and dynamic field of study.
- Continued research is essential for a complete understanding of olfaction.
- This review consolidates current knowledge and points to future directions.
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