Jove
Visualize
Contact Us

Related Experiment Videos

Fibroids and menorrhagia.

C P West, M A Lumsden

    Bailliere'S Clinical Obstetrics and Gynaecology
    |June 1, 1989
    PubMed
    Summary

    Uterine fibroids cause heavy menstrual bleeding, often resistant to treatment. While LHRH agonists shrink fibroids short-term, long-term use is limited; further research is needed for alternatives to hysterectomy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgery and minimally invasive treatments for uterine fibroids.

    The Cochrane database of systematic reviews·2025
    Same author

    Investigating abnormal uterine bleeding in reproductive aged women.

    BMJ (Clinical research ed.)·2022
    Same author

    Endophyte infection effects on stomatal conductance, osmotic adjustment and drought recovery of tall fescue.

    The New phytologist·2021
    Same author

    Premature ovarian insufficiency: a toolkit for the primary care physician.

    Climacteric : the journal of the International Menopause Society·2021
    Same author

    Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review.

    BJOG : an international journal of obstetrics and gynaecology·2019
    Same author

    First Report of Rust Caused by Puccinia emaculata on Switchgrass in Arkansas.

    Plant disease·2019
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Gynecology
    • Reproductive Medicine

    Background:

    • Uterine fibroids are a significant cause of menorrhagia (heavy menstrual bleeding).
    • The exact mechanisms linking fibroids to excessive blood loss are not fully understood.
    • Conventional medical treatments for fibroids are often ineffective.

    Purpose of the Study:

    • To review the current understanding of uterine fibroid etiology, diagnosis, and treatment.
    • To explore the role of new developments, such as LHRH agonists, in managing fibroids.
    • To assess the potential of medical therapies as alternatives to hysterectomy.

    Main Methods:

    • Review of existing literature on uterine fibroids and menorrhagia.
    • Discussion of recent advancements in diagnostic and therapeutic approaches.
    • Analysis of the efficacy and limitations of hormone therapies, including LHRH agonists.

    Main Results:

    • LHRH agonists are the only medical agents that cause significant uterine fibroid shrinkage.
    • Fibroid regression with LHRH agonists is temporary, necessitating further treatment or surgery.
    • Hysterectomy remains the primary treatment, though endoscopic surgery offers conservative options.

    Conclusions:

    • LHRH agonists provide short-term symptom relief and can be useful adjuncts to surgery.
    • Prolonged ovarian suppression limits the long-term use of LHRH agonists.
    • Further research is required to establish safe, effective, and cost-effective medical alternatives to hysterectomy for menorrhagia due to fibroids, particularly for women desiring fertility preservation.

    Related Experiment Videos