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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Oral Drug Delivery Systems: Introduction01:23

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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Porous Silicon Microparticles for Delivery of siRNA Therapeutics
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Efficient drug delivery using SiO2-layered double hydroxide nanocomposites.

Li Li1, Zi Gu2, Wenyi Gu1

  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia.

Journal of Colloid and Interface Science
|March 2, 2016
PubMed
Summary

We developed novel silica-coated magnesium aluminum layered double hydroxide (SiO2@MgAl-LDH) nanocomposites for enhanced drug delivery. These optimized nanocomposites effectively delivered methotrexate, inhibiting human osteosarcoma cell growth.

Keywords:
Drug deliveryFunctionalizationLayered double hydroxide (LDH)NanocompositesSelf-assembly

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Layered double hydroxide (LDH) nanoparticles show promise for drug and siRNA delivery.
  • Developing stable and well-dispersed nanocomposites is crucial for effective drug delivery systems.

Purpose of the Study:

  • To create silica dot-coated MgAl-LDH (SiO2@MgAl-LDH) nanocomposites with improved dispersibility and controlled size for drug delivery applications.
  • To optimize the synthesis of SiO2@MgAl-LDH nanocomposites by tuning parameters like material ratio, temperature, and time.

Main Methods:

  • Nanodot-coating strategy using SiO2 to modify MgAl-LDH nanoparticles.
  • Systematic adjustment of synthesis parameters (mass ratio, temperature, time) to achieve optimal nanocomposite properties.
  • Characterization of nanocomposite morphology, size, and dispersibility.
  • In vitro evaluation of drug delivery efficacy using methotrexate (MTX) and U2OS human osteosarcoma cells.

Main Results:

  • Optimal SiO2@MgAl-LDH nanocomposites exhibited uniform deposition of 10-15nm SiO2 nanodots on 110nm MgAl-LDH platelets.
  • The resulting nanocomposites had an average hydrodynamic diameter of 170nm and good dispersibility.
  • Methotrexate delivered by SiO2@MgAl-LDH nanocomposites demonstrated significant inhibition of U2OS cell growth.

Conclusions:

  • The nanodot-coating strategy successfully produced well-dispersed SiO2@MgAl-LDH nanocomposites suitable for drug delivery.
  • These nanocomposites show potential as effective carriers for chemotherapy drugs like methotrexate in treating osteosarcoma.
  • Further research into optimizing these nanocomposites could lead to advanced targeted cancer therapies.