[Formulation Optimization of Zuojin Floating-Bioadhesive Pellets by Central Composite Design-Response Surface...

Area of Science:

• Pharmaceutical Sciences
• Formulation Development
• Drug Delivery Systems

Context:

• Optimizing oral drug delivery systems is crucial for therapeutic efficacy.
• Floating-bioadhesive pellets offer prolonged gastric residence time and controlled release.
• Zuojin pellets require precise formulation for desired performance characteristics.

Purpose:

• To optimize the formulation of Zuojin floating-bioadhesive pellets using central composite design-response surface methodology (CCD-RSM).
• To identify optimal levels of sodium bicarbonate, HPMC, and MCC for pellet formulation.
• To achieve multi-objective simultaneous optimization of pellet properties.

Summary:

• The study employed CCD-RSM to optimize Zuojin floating-bioadhesive pellets, with sodium bicarbonate, HPMC, and MCC as independent variables.
• A quadratic model best described the relationship between formulation variables and pellet properties (roundness, 12h floating rate, in vitro release).
• The optimized formulation demonstrated predicted values close to actual values, with deviations less than 5%.

Impact:

• The findings provide a statistically validated method for optimizing complex drug delivery formulations.
• Successful optimization of Zuojin pellets can lead to improved therapeutic outcomes through controlled drug release.
• This study demonstrates the utility of CCD-RSM for multi-objective optimization in pharmaceutical development.