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Updated: Mar 24, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Ynol Ethers: Synthesis and Reactivity
Charlie Verrier1, Sébastien Carret1, Jean-François Poisson2
1Université Grenoble Alpes, Département de Chimie Moléculaire (SERCO), UMR-5250 CNRS, IMCG FR-2607, 38041 Grenoble, France.
Abstract:
Ynol ethers are highly valuable substrates offering a wide range of reactivity. These highly electron-rich heterosubstitued alkynes can be of great synthetic potential. In this mini-review, the different methods for the synthesis of ynol ethers are first presented, divided in three main approaches involving a β-elimination, a carbene rearrangement and a direct oxidation of an alkyne. Their reactivity is then summarized underlying their synthetic utility. This non-exhaustive review aims at presenting the intrinsic reactivity of these compounds, still underexploited in synthesis.
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