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Sabrina Capece1, Fabio Domenici2, Francesco Brasili3

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Researchers developed novel hybrid shell droplets for ultrasound imaging. These droplets transform into stable microbubbles under ultrasound and revert to their original state, offering potential as advanced ultrasound contrast agents.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Acoustics

Background:

  • Hybrid shell droplets encapsulating decafluoropentane (DFP) show promise for ultrasound (US) imaging.
  • Current limitations in microbubble stability and recovery hinder their widespread application.

Purpose of the Study:

  • To investigate the interfacial properties and stability of hybrid shell droplets for ultrasound imaging applications.
  • To characterize the transformation of these droplets into microbubbles and their subsequent recovery.

Main Methods:

  • Droplet fabrication via dextran methacrylate deposition on surfactants, stabilized by UV curing.
  • Ultrasound irradiation to induce core evaporation and microbubble formation.
  • Pendant drop method and indirect liquid-gas transition point determination for interfacial tension.
  • Confocal microscopy for imaging microbubble re-condensation and relaxation.

Main Results:

  • UV-cured polymer shells create stable, elastomeric membranes (approx. 300 nm thick) with viscoelastic behavior.
  • Droplets transform into microbubbles upon US irradiation but exhibit remarkable stability and recover their initial state post-irradiation.
  • Interfacial tension and microrheology parameters of the complex shell structure were determined.

Conclusions:

  • The viscoelastic nature of the hybrid shell contributes to the unusual stability of droplets during phase transitions and enables recovery.
  • These findings support the potential of these hybrid shell droplets as robust and recoverable ultrasound contrast agents (UCAs).