Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

743
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
743
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

616
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
616
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

671
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
671

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Marked Improvement in Pulmonary Arterial Hypertension in 3 Patients with a History of Amphetamine-like Drug use and Comorbidities.

The open respiratory medicine journal·2026
Same author

Innominate Artery Compression Syndrome Following Endovascular Stenting of Tracheoinnominate Artery Fistula.

World journal for pediatric & congenital heart surgery·2026
Same author

Single Ventricle Infant Deaths Without Transplant Referral: Room for Improvement?

Pediatric cardiology·2026
Same author

An important caveat to Evans' Rule for pediatric left ventricular hypertrophy.

The American journal of emergency medicine·2026
Same author

Seroprevalence and Risk Factors for Hepatitis E Virus in a Metropolis of Northeastern Brazil: A Population-Based Survey.

Zoonoses and public health·2026
Same author

Significant Congenital Cardiovascular Malformations and Falling Birth Rates: The Nevada Experience.

Pediatric cardiology·2026

Related Experiment Video

Updated: Mar 24, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.8K

Hybrid Palliation for Ductal-Dependent Systemic Circulation.

William N Evans1,2, Alvaro Galindo3,4, Abraham Rothman3,4

  • 1Children's Heart Center Nevada, 3006 S. Maryland Pkwy Ste. 690, Las Vegas, NV, 89109, USA. wnevans50@aol.com.

Pediatric Cardiology
|March 3, 2016
PubMed
Summary

Hybrid palliation offers excellent midterm survival for neonates with two functional ventricles (2V) or low-risk single functional ventricle (1V) congenital heart disease. However, high-risk single functional ventricle (1V) patients experience significantly worse outcomes.

Keywords:
Ductal-dependent systemic circulationHybrid procedureHypoplastic aortic archHypoplastic left heart syndrome

More Related Videos

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

2.5K
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.4K

Related Experiment Videos

Last Updated: Mar 24, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.8K
Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

2.5K
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.4K

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Surgery
  • Neonatal Intensive Care

Background:

  • Ductal-dependent systemic circulation presents a critical challenge in neonates.
  • Hybrid palliation strategies aim to improve outcomes for these complex cases.
  • Risk stratification is crucial for predicting outcomes in neonatal cardiac surgery.

Purpose of the Study:

  • To evaluate the midterm survival rates of neonates with ductal-dependent systemic circulation undergoing hybrid palliation.
  • To assess the impact of a risk factor (RF) score on outcomes in different patient subgroups.
  • To compare the efficacy of hybrid palliation across varying degrees of ventricular function and risk.

Main Methods:

  • Retrospective review of 91 neonates with ductal-dependent systemic circulation (August 2007 - October 2015).
  • Patients stratified into three groups based on a risk factor (RF) score: high-risk 2V (RF=3), low-risk 1V (RF=0-1), and high-risk 1V (RF≥2).
  • Midterm survival (median 4 years) analyzed across the three risk-stratified groups.

Main Results:

  • Excellent midterm survival observed in high-risk 2V (95%) and low-risk 1V (91%) groups.
  • Significantly lower midterm survival in the high-risk 1V group (15%).
  • Statistical significance (p=0.001) highlights the disparity in outcomes based on risk stratification.

Conclusions:

  • Hybrid palliation demonstrates excellent midterm results for specific neonatal cardiac conditions (high-risk 2V, low-risk 1V).
  • High-risk 1V neonates with ductal-dependent systemic circulation face considerably worse outcomes with current hybrid palliation strategies.
  • Risk factor scoring effectively identifies patient subgroups with divergent prognoses, informing clinical decision-making.