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Related Experiment Video

Updated: Mar 24, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

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Published on: March 9, 2015

Modified immunotherapy for alopecia areata.

Takashi Yoshimasu¹, Fukumi Furukawa²

¹Department of Dermatology, Wakayama Medical University, Japan; Department of Dermatology, Arida Municipal Hospital, Japan.

Autoimmunity Reviews

|March 3, 2016

Summary

A modified squaric acid dibutylester (SADBE) immunotherapy for alopecia areata (AA) without initial high-dose sensitization achieved comparable efficacy to conventional methods. This approach may improve patient compliance by reducing severe contact dermatitis.

Keywords:

Alopecia areata DPCP Immunotherapy Pulse SADBE

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Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

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Published on: January 27, 2018

Area of Science:

Dermatology
Immunotherapy
Alopecia Areata Research

Background:

Alopecia areata (AA) treatment often involves squaric acid dibutylester (SADBE) immunotherapy.
High initial SADBE concentrations (1%-2%) can cause severe contact dermatitis, reducing patient compliance.

Purpose of the Study:

To evaluate a modified SADBE immunotherapy protocol for AA starting at a low concentration (0.01%) without initial sensitization.
To assess the efficacy and safety of this modified approach, including combination therapy with steroid pulses.

Main Methods:

Gradual dose escalation of SADBE from 0.01% up to 2% based on patient-reported itching or erythema at AA lesions.
Comparison of response rates between modified immunotherapy and conventional SADBE immunotherapy.
Investigation of combination therapy with SADBE and multiple steroid pulse courses.

Main Results:

The modified immunotherapy achieved a 69.4% response rate (25/36), comparable to conventional immunotherapy.
Combination therapy yielded a 73.7% response rate (28/38) but was associated with a higher prevalence of severe AA.
The modified protocol aims to mitigate severe contact dermatitis associated with high-dose SADBE initiation.

Conclusions:

Modified SADBE immunotherapy without initial high-dose sensitization is an effective alternative for treating alopecia areata.
This approach offers comparable efficacy to conventional methods while potentially improving patient tolerance and compliance.
Combination therapy with steroid pulses shows promise but requires careful consideration due to the increased prevalence of severe AA.