Related Experiment Video
Updated: Aug 9, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
Published on: April 20, 2016
Role of Langerhans cells in atopic disease
C A Bruijnzeel-Koomen1, W J Fokkens, G C Mudde
1Swiss Institute of Allergy and Asthma Research, Davos.
Abstract:
So far, the role of antigen-presenting cells in atopic disorders has been underestimated. Recent observations, made in the skin of patients with atopic dermatitis and in the nasal mucosa of patients with allergic rhinitis suggest that Langerhans cells, being tissue-specific dendritic cells with potent antigen-presenting capacity, play an important role in the allergic inflammatory response. Evidence is presented that Langerhans cells even play a crucial role in directing the type of the allergic reaction mechanism.
Related Concept Videos
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Cells of the Adaptive Immune Response
Antigen Presenting Cells
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

