Related Experiment Video
Updated: Aug 17, 2026

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Contribution of eosinophil-derived mediators in asthma
1Swiss Institute of Allergy and Asthma Research, Davos.
Abstract:
The most important eosinophil-derived mediators which may contribute to the pathogenesis of asthma are: major basic protein, eosinophil cationic protein, eosinophil peroxidase, reactive oxygen species, leukotriene C4, and platelet-activating factor. The potency of the eosinophil to release these mediators can be greatly enhanced by eosinophil mobilizing and activating factors such as granulocyte macrophage colony stimulating factor, interleukins 3 and 5, platelet-activating factor, and perhaps leukotriene B4. For the development of more effective anti-asthma drugs it, therefore, seems relevant to unravel and interfere with the steps of eosinophil activation.
More Related Videos
Related Concept Videos
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma I: Introduction

