[VESTIBULAR AND THERMOPROTECTIVE PROPERTIES OF A NEW ACTOPROTECTOR]

Area of Science:

• Pharmacology
• Neuroscience
• Biochemistry

Background:

• 3-hydroxypyridine (3-HP) derivatives are known for their protective qualities.
• Vestibular and thermal protection are critical physiological functions.
• Existing vestibuloprotectors and actoprotectors include promethazine, mexidol, and metaprot.

Purpose of the Study:

• To evaluate the vestibuloprotective and thermoprotective efficacy of a novel 3-HP derivative, 2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate.
• To compare its effects against established reference drugs.

Main Methods:

• Animal experimentation (rats and mice) was employed.
• Vestibuloprotective effects were assessed and compared to promethazine.
• Thermoprotective effects were evaluated and compared to mexidol and metaprot.

Main Results:

• 2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate demonstrated a strong vestibuloprotective effect in rats, outperforming promethazine.
• Its thermoprotective effect in mice was comparable to mexidol and metaprot.
• The compound exhibited competitive efficacy against other 3-HP derivatives like mexidol.

Conclusions:

• 2-ethyl-6-methyl-3-hydroxypyridine L-asparaginate possesses significant vestibuloprotective and thermoprotective properties.
• Its membrane-protective and antioxidative qualities contribute to its efficacy.
• The novel derivative shows potential as a superior or competitive therapeutic agent.