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Updated: Aug 15, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Ultrastructural study of hereditary benign intraepithelial dyskeratosis
Abstract:
Specimens taken from the buccal mucosa of two patients with hereditary benign intraepithelial dyskeratosis (HBID) were studied with the transmission electron microscope. Ultrastructural features were described and compared with those of white sponge nevus and Darier's disease. Ultrastructural findings in HBID revealed the presence of numerous vesicular bodies in immature dyskeratotic cells, densely packed tonofilaments filling the cytoplasm of mature dyskeratotic cells, and the disappearance of cellular interdigitations and desmosomes in mature dyskeratotic cells.
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The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...