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Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer

Masakazu Yashiro1, Tasuku Matsuoka1

  • 1Masakazu Yashiro, Tasuku Matsuoka, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.

World Journal of Gastroenterology
|March 4, 2016
PubMed

Insights

Fibroblast growth factor receptor (FGFR) signaling drives gastric cancer progression and chemoresistance. Inhibiting FGFR signaling with therapeutic agents shows promise for treating gastric cancer, particularly diffuse-type.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Fibroblast growth factor receptors (FGFRs) are crucial for normal cellular functions, including development and tissue maintenance.
  • FGFR signaling is implicated in the growth, spread, and survival of various cancer cells.
  • Alterations in FGFRs, such as mutations and amplifications, are linked to gastric cancer initiation and progression, especially in diffuse-type cancers.

Purpose of the Study:

  • To review the role of FGFR signaling in gastric cancer development, progression, and treatment resistance.
  • To explore FGFR signaling as a potential therapeutic target in gastric cancer.
  • To summarize evidence supporting FGFR inhibition for gastric cancer therapy.

Main Methods:

  • Literature review of studies on FGFR signaling in gastric cancer.
  • Analysis of research on FGFR alterations and their impact on tumorigenesis.
  • Examination of clinical data on FGFR-targeted therapies for gastric cancer.

Main Results:

  • FGFR signaling pathways are significantly involved in gastric cancer cell proliferation, invasion, and survival.
  • FGFR alterations are key drivers in the initiation and progression of gastric cancer.
  • Evidence indicates that inhibiting FGFR signaling can be an effective therapeutic strategy.

Conclusions:

  • The FGFR signaling pathway is a critical factor in gastric cancer pathogenesis.
  • Targeting FGFR signaling represents a promising therapeutic avenue for gastric cancer treatment.
  • Clinical agents inhibiting FGFR signaling demonstrate efficacy in preclinical and clinical settings for gastric cancer.
Keywords:
Fibroblast growth factor receptorGastric cancerSignaling pathwayTargeted therapy

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