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Isavuconazonium sulfate for the treatment of fungal infection

R C Walker1, J D Zeuli2, Z Temesgen3

  • 1Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Drugs of Today (Barcelona, Spain : 1998)
|March 4, 2016
PubMed

Insights

Isavuconazole is a new antifungal medication approved for invasive aspergillosis and mucormycosis. It offers broad-spectrum coverage and a favorable safety profile compared to older azoles.

Area of Science:

  • Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Invasive fungal infections (IFIs) pose significant clinical challenges.
  • Azole antifungals are crucial for treating IFIs.
  • Newer agents are needed to address resistance and improve safety profiles.

Purpose of the Study:

  • To review the current status and potential applications of isavuconazole.
  • To highlight its efficacy in treating invasive aspergillosis and invasive mucormycosis.
  • To compare its safety and drug interaction profile with voriconazole.

Main Methods:

  • Review of clinical trial data and post-marketing surveillance.
  • Pharmacokinetic and pharmacodynamic analyses.
  • Comparative studies with existing antifungal therapies.

Main Results:

  • Isavuconazole demonstrates broad-spectrum activity against yeasts, molds, and dimorphic fungi.
  • Isavuconazonium sulfate is approved for invasive aspergillosis and mucormycosis.
  • Favorable safety and lower drug interaction potential compared to voriconazole.

Conclusions:

  • Isavuconazole is a valuable therapeutic option for specific IFIs.
  • Further research is needed to explore its role in other fungal infections and prophylaxis.
  • Its utility in azole-experienced patients requires further clinical investigation.
Keywords:
AntifungalBAL-8557IsavuconazoleIsavuconazonium sulfateTriazole

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