Visible Light and pH Responsive Polymer-Coated Mesoporous Silica Nanohybrids for Controlled Release
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Published on: July 21, 2017
Guojie Wang1, Jie Dong1, Tingting Yuan1
1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Abstract:
A visible light and pH responsive anticancer drug delivery system based on polymer-coated mesoporous silica nanoparticles (MSNs) has been developed. Perylene-functionalized poly(dimethylaminoethyl methacrylates) sensitive to visible light and pH are electrostatically attached on the surface of MSNs to seal the nanopores. Stimulation of visible light and acid can unseal the nanopores to induce controlled drug release from the MSNs. More interestingly, the release can be enhanced under the combined stimulation of the dual-stimuli. The synergistic effect of visible light and acid stimulation on the efficient release of anticancer drugs from the nanohybrids endows the system with great potential for cancer therapy.
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