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[HORMONAL-GENETIC SCREENING IN PATIENTS, SUFFERING GASTRODUODENAL ULCER HEMORRHAGE]
Klinichna Khirurhiia
|March 5, 2016
Summary
Genetic-hormonal regulation impacts blood loss in gastroduodenal ulcers. Specific gene variations like VKORC1, particularly in women, and estrogen receptor expression may guide future therapies for ulcer hemorrhage.
Area of Science:
- Genetics
- Gastroenterology
- Endocrinology
Background:
- Genetic-hormonal regulation is crucial in gastroduodenal ulcer disease with hemorrhage.
- The clinical significance of certain compensatory steroidogenesis genes is not fully understood.
Purpose of the Study:
- To investigate the role of specific genes (ESR1, VKORC1) and estrogen receptor expression in gastroduodenal ulcer hemorrhage.
- To explore potential genetic markers for predicting hemorrhage risk and guiding therapy.
Main Methods:
- Polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP) were used.
- Immunohistochemical analysis of gastroduodenal mucosa was performed on 63 patients.
Main Results:
- No significant gender-based difference in ESR1 and VKORC1 gene distribution was found, except for VKORC1 genotype A/A, which was more prevalent in women (p < 0.05).
- Gastric fundus showed immunoreactivity to alpha-estrogen receptors in epithelial and stromal cells.
Conclusions:
- Polymorphic gene VKORC1 and estrogen receptor expression are potential targets for pathogenetic therapy in patients experiencing hemorrhage.
- Understanding these genetic factors may improve management of complicated gastroduodenal ulcer disease.
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