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Relationship between lipids and aflatoxin biosynthesis.

C Fanelli1, A A Fabbri

  • 1Dipartimento di Biologia vegetale, Università di Roma La Sapienza, Italy.

Mycopathologia
|September 1, 1989
PubMed
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Lipids are crucial for fungal growth and aflatoxin production. Antioxidants like BHA and BHT can inhibit aflatoxin biosynthesis by impacting fungal growth and lipoperoxidation.

Area of Science:

  • Mycology
  • Food Science
  • Biochemistry

Background:

  • Lipids play a critical role in fungal development.
  • Lipoperoxidation is linked to aflatoxin biosynthesis.
  • Aflatoxins are toxic secondary metabolites produced by certain fungi.

Purpose of the Study:

  • To investigate the role of lipids in fungal growth.
  • To determine the effect of lipoperoxidation on aflatoxin production.
  • To evaluate the efficacy of antioxidants in controlling aflatoxin biosynthesis.

Main Methods:

  • In vitro studies using Aspergillus flavus and Aspergillus parasiticus cultures.
  • In vivo studies on inoculated grains (wheat, maize, sunflower).
  • Treatment with antioxidants such as Butylated hydroxyanisole (BHA), Butylated hydroxytoluene (BHT), and cysteamine.

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Main Results:

  • Antioxidants (BHA, BHT, cysteamine) reduced or blocked aflatoxin output in vitro without affecting fungal growth.
  • In vivo, BHA and BHT significantly decreased aflatoxin production on grains.
  • Antioxidants primarily inhibited fungal growth in vivo, thereby reducing aflatoxin levels.
  • Seed surface lipids serve as a significant carbon source for fungal proliferation in vivo.

Conclusions:

  • Lipids are essential for fungal growth and aflatoxin biosynthesis.
  • Antioxidants demonstrate potential in controlling aflatoxin contamination.
  • Targeting lipoperoxidation and fungal lipid metabolism offers a strategy for aflatoxin mitigation.