Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regeneration in the peripheral nervous system.

S M Hall1

  • 1Department of Anatomy, United Medical and Dental Schools of Guy's Hospital, London.

Neuropathology and Applied Neurobiology
|November 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of sample storage time and temperature on equine complete blood counts.

Journal of equine veterinary science·2026
Same author

Changes in equine complete blood count parameters and inflammatory indices with inflammation.

Journal of equine veterinary science·2025
Same author

The interactive effect of anxiety sensitivity and negative smoking cessation cognitions on reductions in cigarette consumption during acute cessation.

Addictive behaviors·2021
Same author

Phloem transport of (14)C-labelled assimilates in Ricinus.

Planta·2014
Same author

The chemical composition of Ricinus phloem exudate.

Planta·2014
Same author

Phloem transport in Ricinus: Its dependence on the water balance of the tissues.

Planta·2014

Peripheral nerve regeneration in mammals depends on Schwann cells guiding axonal regrowth across injury gaps. Successful repair requires Schwann cells to organize sprouts and bridge gaps, with macrophages aiding debris clearance.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • Mammalian peripheral nerve fibers possess regenerative capacity after injury.
  • Successful regeneration is influenced by injury severity, particularly the gap distance between nerve stumps.
  • Axonal sprouting is an intrinsic response, but organized regrowth requires cellular support.

Purpose of the Study:

  • To elucidate the role of Schwann cells and macrophages in peripheral nerve regeneration.
  • To understand the mechanisms underlying axonal guidance and outgrowth across injury sites.
  • To identify factors influencing the success or failure of nerve repair.

Main Methods:

  • Observational study of axonal regeneration in mammalian peripheral nerves.
  • Analysis of cellular responses (Schwann cells, macrophages) to nerve injury.

Related Experiment Videos

  • Assessment of axonal behavior and organization in relation to interstump gap size and tissue damage.

    • Main Results:

    • Axonal regeneration is successful with minimal gaps (<0.5 cm) and fails with larger gaps (>1 cm) and soft tissue damage.
    • Schwann cells are essential for organizing axonal sprouts into minifascicles and guiding them towards the distal stump.
    • Schwann cells proliferate, co-migrate with axons, provide a supportive substrate, and bridge gaps up to 1 cm.
    • Macrophages clear myelin debris and may interact with Schwann cells via mitogens and cytokines.

    Conclusions:

    • Schwann cells are critical for successful peripheral nerve regeneration by organizing and guiding axonal regrowth.
    • The presence and activity of Schwann cells and macrophages significantly impact the outcome of nerve repair.
    • Understanding these cellular interactions provides insights into promoting nerve regeneration and developing therapeutic strategies.