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Severe Hyponatremia and Immune Nephritis Following an Initial Infusion of Nivolumab

Jeremy W Vandiver1,2, Zachary Singer3, Cara Harshberger4

  • 1University of Wyoming School of Pharmacy, Health Sciences Center, Room 292, 1000 E. University Ave., Dept. 3375, Laramie, WY, 82071, USA. jvandive@uwyo.edu.

Targeted Oncology
|March 5, 2016
PubMed

Anti-programmed cell death-1 (PD-1) antibodies pembrolizumab and nivolumab are becoming increasingly important in the treatment of melanoma and non-small cell lung cancer. These agents are known to induce many immune-related adverse events, but rapid-onset nephritis and immune-related hyponatremia have not been described to date. We describe the case of an adult patient who developed severe hyponatremia and rapid-onset nephritis following the first infusion of nivolumab for metastatic melanoma.

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