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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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A Fractional Order Recovery SIR Model from a Stochastic Process.

C N Angstmann1, B I Henry2, A V McGann1

  • 1School of Mathematics and Statistics, UNSW Australia, Sydney, 2052, Australia.

Bulletin of Mathematical Biology
|March 5, 2016
PubMed
Summary
This summary is machine-generated.

Fractional differential equations model epidemics when recovery times follow a power-law distribution, offering insights into chronic disease dynamics. Simulations show increased infections at equilibrium as fractional order approaches zero.

Keywords:
Epidemiological modelsFractional calculusSIR model

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Area of Science:

  • Epidemiology
  • Mathematical Biology
  • Stochastic Processes

Background:

  • Epidemiological models often use fractional derivatives without clear justification.
  • The relevance of ad hoc fractional models to real-world disease dynamics is uncertain.
  • A need exists for a rigorous derivation of fractional epidemiological models.

Purpose of the Study:

  • To develop a fractional SIR (Susceptible-Infected-Recovered) model for epidemics from an underlying stochastic process.
  • To investigate the conditions under which fractional differential operators naturally arise in epidemiological models.
  • To provide a mathematically sound basis for fractional epidemiological modeling, particularly for chronic diseases.

Main Methods:

  • Developed a SIR model incorporating vital dynamics from a stochastic process.
  • Demonstrated that fractional differential operators emerge when recovery times are power-law distributed.
  • Extended the stochastic derivation to discrete time, enabling stable numerical solutions.
  • Analyzed model consistency with existing SIR models (Kermack-McKendrick, Hethcote-Tudor).

Main Results:

  • Fractional derivatives naturally arise in SIR models with power-law distributed recovery times, modeling chronic disease.
  • The fractional order recovery model is consistent with established SIR models.
  • Simulations confirmed convergence to equilibrium states.
  • The number of infected individuals at endemic equilibrium increases as the fractional order approaches zero.

Conclusions:

  • Fractional calculus provides a natural framework for modeling epidemics with power-law recovery, relevant to chronic diseases.
  • The stochastic derivation offers a robust foundation for fractional epidemiological models.
  • Model behavior indicates that a lower fractional order (closer to zero) leads to higher endemic infection levels.